Set in the South of France in the decade after the First World War, Tender is the Night explores the new world of moneyed leisure found by the first generation of idle-rich Americans to take refuge in the French Riviera, bracketed between the horrors of the Great War and the Great Depression to come. It is the story of a brilliant and magnetic psychiatrist named Dick Diver; the bewitching, wealthy, and dangerously unstable mental patient, Nicole, who becomes his wife; and the beautiful, harrowing ten-year pas de deux they act out along the border between sanity and madness.

F. Scott Fitzgerald deliberately set out to write the most ambitious and far-reaching novel of his career, exper