Merging with a bizarre spiritual force called Genesis, Texan Preacher Jesse
Custer becomes completely disillusioned with the beliefs that he had dedicated
his entire life to. Now possessing the power of "the word," an ability to make
people do whatever he utters, Custer begins a violent and riotous journey across
the country. Joined by his gun-toting girlfriend, Tulip, and the hard-drinking
Irish vampire, Cassidy, the Preacher loses faith in both man and God as he
witnesses dark atrocities and improbable calamities during his exploration of
America.